One step to purchase Etorphine (M99)

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Order Etorphine (M99) Powder Online

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Description

Buy Etorphine (M99) Powder Online

Buy Etorphine (M99) Powder online has a potent effect on depressing the respiratory centers of the CNS thus resulting in apnea being commonly seen in immobilized animals.


Etorphine (M99) Powder is chemically related to morphine. In laboratory animals, etorphine resembles morphine by causing analgesia, catatonia, blockade of conditional reflexes, and anti-diuretic effect. It also resembles morphine by causing excitement in mice, cats and bradycardia and hypotension in rats, dogs, cats and monkeys. When given subcutane- ously, etorphine is 1000-4000 times more potent than morphine as an analgesic, depending on the test situation. Its use for immobilizing game animals results largely from its ability to cause catatonia at very low dose levels.


The chemical name for etorphine hydrochloride is 6,14-Ethenomorphinan-7-methanol, 4,5-epoxy-3-hydroxy-6-methoxy-ά,17-dimethyl-ά-propyl-, (5ά,7á-(R))- hydrochloride.

The approved generic name for this compound is diprenorphine, and the chemical name is N-cyclopropylmethyl-6, 14-endoetheno-7-(1-hydroxy-1-methylethyl)tetrahydro-nororipavine. It is a potent morphine antagonist with an action similar to nalorphine. Its potency, however, was stated by Bentley et al. (1965) to be up to 35 times greater than nalorphine and to have a duration of action two to three times as long. In game animals it produced a rapid and complete reversal of the immobilisation produced by M99. Although it appears that there may be some degree of species variation in the response in practice it has been found that a dosage ratio M5050 to M99 of 1:1 is perfectly satisfactory i.e. 1.3mg diprenorphine produces reversal of the immobilising action of 1mg etorphine.


Safety Precautions Etorphine (M99) Powder

Firstly, Keep M99 and M5050 together.
Ensure that there is sufficient M5050 to reverse the effects of M99.
Load the M5050 syringe first and keep it to hand throughout the procedure.
Load the M99 syringe well clear of the patient or assisting persons.
Use a disposable syringe.
Discard empty M99/M5050 vials – never reuse containers for other drugs.
Always ensure that a syringe loaded with an appropriate antidote for human use is at hand (Narcan).
DO NOT confuse different preparations.
DON’T use a syringe that has previously been use for M99 or any other drugs.
DON’T carry a syringe loaded with M99 in your pocket. Syringes loaded with M99 should carry a needle guard.


Further advice on handling Large Animal M99

Once the required dose of M99 has been withdrawn from the vial it is strongly recommendedd that the needle be remove from the syringe and discard into a closed container. A sterile needle should then be insert into the injection site and the syringe connectedd to it.
Wear gloves.
Do not pressurise the contents of the vial.
An eye and skin wash should be made available.
An assistant capable of giving an injection of reversing agent should be present whenever Large Animal M99 is used.
The veterinary surgeon should fully brief the assistant on the procedure and indicate whether M5050 is to be consideredd as an antidote in the event of personal accident.
To minimise risk of accident when injecting M99 i.v., the Portex Minivein or similar equipment can be used.
Immobilise only one animal at a time and keep it under constant supervision at all stages.


Accident Procedure

M99 is a very potent neuroleptanalgesic which is highly toxic in man. It causes dizziness, nausea and pinpoint pupils, followed by respiratory depression, lowered blood pressure, cyanosis and, in extreme cases, loss of consciousness and cardiac arrest.

If there is any danger that M99 may have been inject or absorb, the following steps should be taken IMMEDIATELY!!!!! In case of:

Accidental injection (including needle scratch).
Splashing into eyes, mouth or nose.
Spillage on to the skin or immediate clothing.
BEFORE CALLING MEDICAL ASSISTANCE, INJECT A REVERSING AGENT. In case of 1) or 2), immediate washing with plenty of water may prevent significant absorption, but THIS SHOULD NEVER BE ASSUMED. THE DATA SHEET OR PACK LEAFLET SHOULD BE HANDED TO THE ATTENDING DOCTOR.

 

One step to purchase Etorphine (M99)

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